Below is a chart showing which purifying method is best for each nature.
Nature/Method
1
2
3
4
5
Adamant
+
-
+
=
-
Bashful
--
=
-
+
++
Bold
+
-
++
=
--
Brave
++
-
+
-
-
Calm
+
=
=
+
+
Careful
-
=
-
+
+
Docile
-
++
=
-
=
Gentle
--
=
-
++
+
Hardy
+
=
+
--
=
Hasty
++
=
-
--
+
Impish
++
=
+
--
-
Jolly
+
=
=
--
+
Lax
=
-
+
-
+
Lonely
--
+
+
--
++
Mild
-
-
-
+
++
Modest
-
=
-
++
=
Naive
=
=
+
-
-
Naughty
+
-
++
-
-
Quiet
=
=
=
=
=
Quirky
++
-
--
++
-
Rash
-
=
=
=
+
Relaxed
-
-
-
++
+
Sassy
++
--
+
-
=
Serious
=
+
=
=
-
Timid
--
+
--
++
+
++ ((Method is extremely effective))
+ ((Method is very effective))
= ((Method is effective))
- ((Method isn't as effective))
-- ((Method is barely effective))